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I have been on Effexor XR for 8 years. I was on 75mg once a day for the first 8 following my first year of college. A couple months ago I started exhibiting symptoms of panic disorder again, very severely. I was upped to 150mg once a day, seemed fine for a couple weeks, but upped again to 187.5mg once a day since I was still having panic attacks. Generally I feel like it is working - I know that there are some people on much higher dosages, and it is just a matter of finding your right dosage.

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I was on the lowest dose of Effexor XR and loved how I felt -- it just took the edge off of everything and made me less irritable and more easygoing. What I didn't like is the 40lb weight gain and increased blood pressure that came with it. My blood pressure went back to normal when I quit taking it, but getting the weight off is a real struggle. I'm doing Weight Watchers AND working with a trainer twice a week (plus doing cardio on other days) and the weight is coming off slowly. Before Effexor, I could easily drop 10lbs doing Weight Watchers only. So, yeah, I think it killed my metabolism. Although I really liked how I felt and functioned, I wouldn't have taken it if I'd known about the [seemingly permanent"> weight gain.

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